Porcilis Begonia
Description and Vaccination Program
Description
Porcilis AD Begonia is based on the virus strain NIA-3 which has been made tk and gE
negative (tk-, gE-). The resulting vaccine strain is genetically stable, highly efficacious,
safe and does not cause latency in pigs. The gE deletion allows field infections to be
differentiated from vaccination responses. Dissolving the vaccine in Diluvac Forte enhances
the immune response.
Composition
Each dose contains as active component at least 105.5TCID50 of Aujeszky’s
disease virus strain Begonia. The vaccine is dissolved in Diluvac Forte.
Formulation
The vaccine is a freeze-dried live attenuated vaccine. It must be reconstituted before use.
Indications
Active immunisation of pigs against Aujeszky’s disease virus infections (Pseudorabies).
Vaccination
Fattening pigs:
When maternally derived antibodies (MDA) are not present, piglets can be vaccinated as early as 1 week of
age without any problems. Immunity after a single injection will last the whole of the fattening period,
or at least until 6 months of age. When MDA are present, piglets can be given a single dose at 14 weeks of age.
Protection will last the whole of the fattening period. When there is a risk of early infection,
pigs carrying varying levels of MDA can be vaccinated from 10 weeks of age onwards and should be re-vaccinated
at 14 weeks of age, but no earlier than 4 weeks after the first dose.
Breeding pigs:
Basic vaccination: as for fattening pigs.
Repeat vaccinations:
Eradication: at 4 month intervals, three times per year as a herd vaccination program.
Control: end of each pregnancy, not later than 2 weeks before farrowing.
Method of administration
2 ml of the reconstituted product by intramuscular injection.
Withholding period
None
Presentation
Vaccine: Glass vials containing a freeze dried plug, equivalent to 10, 25, 50 or 100 doses.
Diluent: Glass bottles containing 20, 50, 100 or 200 ml of diluent.
Storage
Vaccine: Store at a temperature of 2-8°C. Protect from light. Do not freeze.
Diluent: Store at room temperature.
Contra-indications
Young animals with maternal antibodies may need re-vaccination (see vaccination scheme).
There have been occasional reports of unwanted reactions to vaccination with Porcilis AD Begonia.
These side-effects are likely to be closely related to certain specific conditions prevailing on
the farm and are normally of a transient nature.
Porcilis AD Begonia should not be used in dogs.
Further information
This strain synthesises neither thymidine kinase (tk-) nor the glycoprotein E (gE-).
Animals immunised with this vaccine can be distinguished serologically (gE based test)
from animals infected with field virus, making Porcilis AD Begonia an essential component
in eradication programs. The use of Diluvac Forte results in higher antibody titres,
improved protection and reduced AD virus excretion, compared to using traditional aqueous adjuvants.
Precautions
- Vaccinate healthy pigs only
- Use the vaccine immediately after reconstitution
- Not to be used in dogs
- Use sterile injection equipment
- Mixing with other vaccines is generally not recommended. There are however published data available on the combination with the product Porcilis APP.